U.S. Customs and Border Protection officers assigned to the Calexico West port of entry discovered 223 packages of methamphetamine and heroin hidden throughout a pick-up truck. CBP officers encountered a 35-year-old male U.S. citizen driving a 2020 pick-up truck. At the time of encounter, the driver was applying for entry into the United States from Mexico. A CBP officer performing the primary inspection referred the driver for further examination at the secondary inspection area. CBP officers observed anomalies and irregularities during a non-intrusive (X-ray) examination of the vehicle. A CBP canine enforcement team responded to the scene and alerted them to the presence of narcotics. CBP officers discovered and extracted 223 packages from the rear passenger door, spare tire, and gas tank area of the pick-up truck. The narcotics were field tested as methamphetamine with a total weight of 126.06 pounds and heroin with a weight of 7.84 pounds. The estimated street value of the narcotics is $410,553. The driver was detained and turned over to Homeland Security Investigations for further processing. CBP officers seized the vehicle and narcotics.